Title: Sequelae of radiation facial epilation (North American Hiroshima maiden syndrome).
Authors: Rosen IB, Walfish PG
Journal: Surgery 1989 Dec;106(6):946-50
PMID: 2588120, UI: 90069848
Affiliated institution: Department of Surgery, Mount Sinai Hospital, University of Toronto School of Medicine, Ontario, Canada.
Radiation for benign problems of the head and neck area has been uniformly recognized as unacceptable practice. This includes epilation for facial hirsutism. Twelve such patients, recently encountered, have characteristic radiodermatitis facies and have demonstrated multisite neoplastic involvement–including skin, thyroid, parathyroid, salivary gland, oral cavity, facial skeleton, and breast–and have also undergone extensive dermatologic treatment of complications of radiodermatitis. There was one cancer death, and three patients are alive with cancer. Such patients have a superficial resemblance to the Hiroshima maiden group of young women who survived atomic bombing and experienced severe facial burns, necessitating extensive plastic surgery. As atomic survivors they are at increased risk for cancer of thyroid, salivary gland, lung, breast, bone marrow, and gastrointestinal tract. The North American Hiroshima maiden should warrant easy clinical recognition and require lifetime scrutiny for multisite neoplastic disease.