Lesiewicz, 1983 (topical-ODC & hair growth)

Lesiewicz, 1983

Title: Antizyme release is an early event in ornithine decarboxylase induction by hair plucking.

Authors: Lesiewicz J, Goldsmith LA

Journal: J Invest Dermatol 1983 Feb;80(2):97-100

PMID: 6822744, UI: 83110316

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Plucking of hair from the dorsal skin of rats resulted in a rapid decrease in ornithine decarboxylase (ODC) activity. A significant loss of activity did not occur in other skin enzymes under the same conditions and in vivo incorporation of [3H]-leucine in skin was not significantly decreased 60 min immediately following hair plucking. Treatment of ODC enzyme preparations with 10% (NH4)2SO4 resulted in recovery of approximately 75% greater ODC activity than in untreated samples, suggesting the presence of an inhibitor (antizyme). ODC inhibitor was detected in plucked skin; inhibitor levels increased after treatment of plucked skin extracts with 10% (NH4)2SO4.