Rosen, 1989  Title: Sequelae of radiation facial epilation
(North American Hiroshima maiden syndrome).
Authors: Rosen IB, Walfish PG
Journal: Surgery 1989 Dec;106(6):946-50
PMID: 2588120, UI: 90069848
Affiliated institution: Department of Surgery,
Mount Sinai Hospital, University of Toronto School of Medicine,
Ontario, Canada.
Radiation for benign problems of the head and neck area has been
uniformly recognized as unacceptable practice. This includes epilation
for facial hirsutism. Twelve such patients, recently encountered,
have characteristic radiodermatitis facies and have demonstrated
multisite neoplastic involvement--including skin, thyroid, parathyroid,
salivary gland, oral cavity, facial skeleton, and breast--and
have also undergone extensive dermatologic treatment of complications
of radiodermatitis. There was one cancer death, and three patients
are alive with cancer. Such patients have a superficial resemblance
to the Hiroshima maiden group of young women who survived atomic
bombing and experienced severe facial burns, necessitating extensive
plastic surgery. As atomic survivors they are at increased risk
for cancer of thyroid, salivary gland, lung, breast, bone marrow,
and gastrointestinal tract. The North American Hiroshima maiden
should warrant easy clinical recognition and require lifetime
scrutiny for multisite neoplastic disease.
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