Johannsen, 1978  Title: [Pathomorphology of radiation sickness
in sheep following whole body roentgen irradiation]. [Article
in German]
Authors: Johannsen U, Mehlhorn G, Koch F, Neumeister
K, Panndorf H
Journal: Arch Exp Veterinarmed 1978;32(4):537-56
PMID: 727869, UI: 79081535
Whole-body X-ray treatment was experimentally applied (380 median-line
dosage) to eight Merino mutton sheep aged approximately one year.
Five of the test animals were lost between 16 and 25 days after
irradiation. A great diversity of pathomorphological changes was
recorded from organs and tissues, and the most important pathological
processes which occurred concomitantly with acute to subacute
radiation syndrome of sheep were defective haematopoiesis, septico-toxic
processes, haemorrhagic diathesis, and partial epilation. Severe
damage to the organs involved in haematopoiesis was one of the
primary pathological processes and reflected mainly in lymphopenia,
agranulocytosis, and thrombocytopenia, in other words, with lymphopoieses,
granulopoiesis, and thrombocytopoiesis particularly involved.
Insufficiency of cellular (and humoral) defence would obviously
cause germ flooding of the organism, starting from the intestine,
and eventually lead to septic intoxication. Haemorrhagic diathesis
was found to occur only short of death and is thought to result
from thrombocytopenia due to damage to thrombopoiesis as well
as from septico-toxic effects upon the blood coagulation and partitioning
vascular system. Loss of wool (epilation) was recordable only
from neck and shoulder regions, and even there it was on the decline.
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