Berry, 1976  Title: Skin response to X-irradiation in the
guinea-pig.
Authors: Berry RJ, Mole RH, Barnes DW
Journal: Int J Radiat Biol Relat Stud Phys
Chem Med 1976 Dec;30(6):535-41
PMID: 1087293, UI: 77070773
Skin reaction to X-irradiation has been studied in the albino
guinea-pig; early response in limited-field irradiations of the
flank is comparable to that commonly seen in rodents, swine and
man, and is dose-dependent with a dynamic range from mild erythema
to moist desquamation. The peak early skin reaction is seen between
14 and 21 days after irradiation, and declines before 30 days
except at the highest doses used. Fractionation of the X-ray dose
at 24 hours results in a 'sparing' of about 340 rad. Permanent
partial epilation is detectable at doses in excess of 1400 rad,
and complete epilation at 1 year occurs in 50 per cent of irradiated
fields at 1740 rad. Twenty-four hour two-dose fractionation results
in a 'sparing' of about 500 rad for epilation. Palpable dermal
'fibrosis' is detectable at 3 months after irradiation in fields
given more than 2070 rad, and at 1 year after irradiation in fields
given more than 1800 rad; 50 per cent of fields showed palpable
'fibrosis' at 1 year at 1930 rad. Unlike domestic swine and man,
skin fields in the guinea-pig showed no dimensional contraction
after X-ray doses which produced gross early skin damage.
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