Soler, 1996  Title: Modulation of murine hair follicle function
by alterations in ornithine decarboxylase activity.
Authors: Soler AP, Gilliard G, Megosh LC, O'Brien
TG
Journal: J Invest Dermatol 1996 May;106(5):1108-13
PMID: 8618048, UI: 96210374
Affiliated institution: Lankenau
Medical Research Center, Wynnewood, Pennsylvania 19096, USA.
Cited in:
Mice that overexpress a mutated ornithine decarboxylase (ODC)
transgene in outer root sheath keratinocytes of the hair follicle
were used to study the role of this enzyme in regulating hair
follicle structure and function. These transgenic mice have a
normal first hair cycle, but lose their hair completely beginning
2-3 wk after birth. Transgene overexpression in follicular keratinocytes
is first detected at day 12 after birth, coincident with the development
of follicular cysts in the upper portion of the dermis. The onset
of keratin 6 expression also begins around day 12; because the
promoter/regulatory region of the bovine keratin 6 gene was used
to target ODC transgene expression of hair follicle keratinocytes,
these data demonstrate the faithful temporal and cell type-specific
expression of the K6 -driven transgene. The ODC inhibitor 2-difluoromethylornithine
could prevent hair loss and partially normalize skin histology
if administered before the onset of ODC overexpression. 2-Difluoromethylornithine
could also reactivate hair growth in animals with complete hair
loss. Our results suggest that ODC is an important regulatory
gene for the mouse hair follicle.
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