Probst, 1975  Title: Ornithine decarboxylase activity in
relation to DNA synthesis in mouse interfollicular epidermis and
hair follicles.
Authors: Probst E, Krebs A
Journal: Biochim Biophys Acta 1975 Oct 1;407(2):147-57
PMID: 1182178, UI: 76040127
Affiliated institution:
Cited in:
The relationship between ornithine decarboxylase (L-ornithine
carboxylyase, EC 4.1.1.17) activity and DNA synthetic activity
was studied in mouse epidermis. Interfollicular epidermis and
hair follicles were investigated separately. It was found that,
in hair follicles, the variations of DNA replicative activity,
which are reflected in the cyclic growth of hair, are paralleled
by corresponding changes in ornithine decarboxylase activity.
In both interfollicular epidermis and hair follicles, stimulation
of DNA synthetic activity by plucking of hair induced a rapid
and marked increase in ornithine decarboxylase activity. The relationship
of steady-state and induced ornithine decarboxylase activity to
DNA synthetic activity was compared in hair follicles and interfollicular
epidermis. A correlation between the activity of this enzyme and
DNA replication was found thereby in each of these tissues.
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