Ogawa, 1983  Title: Regulation mechanisms of hair growth.
Authors: Ogawa H, Hattori M
Journal: Curr Probl Dermatol 1983;11:159-70
PMID: 6140129, UI: 84083467
Affiliated institution:
Cited in:
The dorsal resting hair of C3H mice at various ages was shaved,
thus activating the hair into the anagen stage. New hair growth
after shaving was not uniform in the various age groups. Furthermore,
an increasing delay in hair regrowth was observed as the mice
became older (20, 66, 188, and 312 days). In the biochemical analysis
of hair regrowing and nongrowing skins after shaving, activities
of ornithine decarboxylase, transglutaminase, and alkaline phosphatase
had higher values in the extract of the hair regrowing area compared
with that in the nongrowing area. In studying the effects of various
physical and chemical treatments on hair growth after shaving,
repeated shaving was in itself clearly shown to stimulate hair
growth. Amongst all of the treatments that were applied, topical
application of TPA was most able to accelerate hair regrowth,
followed by UV irradiation and retinoic acid treatment. Suppression
of hair regrowth was observed in PUVA, DHT, and estradiol; and
complete inhibition was seen in the animals treated with betamethasone
valerate. In biochemical studies, a relatively good correlation
was observed between the rate of hair regrowth and skin ODC activities
after treatment.
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