Nancarrow, 1999  Title: Dynamic expression of ornithine decarboxylase
in hair growth.
Authors: Nancarrow MJ, Nesci A, Hynd PI, Powell
BC
Journal: Mech Dev 1999 Jun;84(1-2):161-4
PMID: 10473133, UI: 99400112
Affiliated institution: Department
of Animal Science, University of Adelaide, South Australia, Australia.
m.nancarrow@prospect.anprod.csiro.au
Cited in:
Ornithine decarboxylase (ODC) is the key enzyme in the synthesis
of polyamines, small cationic molecules believed to have a role
in many cellular processes such as cell migration, proliferation
and differentiation. We show that ODC expression is associated
with cell proliferation and commitment in hair follicle development
and hair growth. In embryonic epidermis, ODC is expressed in ectodermal
cells at sites where follicles develop, and persists in cells
at the leading edge of the follicle placode. ODC is abundantly
expressed in proliferating bulb cells of anagen follicles, except
for a pocket of cells at the base of the bulb. Entry of the follicle
into catagen is accompanied by a down-regulation of ODC expression,
which is not resumed until a new follicle is initiated. In vibrissae,
ODC expression is more complex. ODC is expressed not only in the
bulb but also in the hair shaft, presenting a striking biphasic
pattern. Additionally, ODC is expressed in a group of outer root
sheath cells in the vicinity of the follicle bulge, the putative
site of hair follicle stem cells.
|
|
hair removal
facts
for consumers
