Morrison, 1978  Title: Ornithine decarboxylase in rat skin.
Authors: Morrison DM, Goldsmith LA
Journal: J Invest Dermatol 1978 Jun;70(6):309-13
PMID: 649976, UI: 78172660
Affiliated institution:
Cited in:
Ornithine decarboxylase (ODC; E.C.4.1.1.17) activities can be
stimulated 2-10 fold in rat epidermis and dermis by hair plucking.
Stimulation does not involve the removal of a soluble ODC inhibitor.
ODC activity in the dermis and whole skin decreased with aging,
while the epidermis showed little change. The apparent Km for
ornithine and the heat stability of ODC in plucked and unplucked
skin were similar. ODC was assayed in plucked and unplucked skin
of rats fed diets containing between 2 and 24% protein. Activities
in both plucked and unplucked skin were higher in the animals
fed diets with higher protein contents. ODC levels were positively
correlated with the weight changes undergone by rats on controlled-protein
diets. In animals restricted to 2% protein diets and rehabilitated
with 16% protein diets, enzyme levels were increased after 2 days
rehabilitation and peaked after 5 days rehabilitation. The responsiveness
of ODC to changes in dietary protein may be useful in the diagnosis
of protein malnutrition.
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