Lesiewicz, 1983  Title: Antizyme release is an early event in
ornithine decarboxylase induction by hair plucking.
Authors: Lesiewicz J, Goldsmith LA
Journal: J Invest Dermatol 1983 Feb;80(2):97-100
PMID: 6822744, UI: 83110316
Affiliated institution:
Cited in:
Plucking of hair from the dorsal skin of rats resulted in a rapid
decrease in ornithine decarboxylase (ODC) activity. A significant
loss of activity did not occur in other skin enzymes under the
same conditions and in vivo incorporation of [3H]-leucine in skin
was not significantly decreased 60 min immediately following hair
plucking. Treatment of ODC enzyme preparations with 10% (NH4)2SO4
resulted in recovery of approximately 75% greater ODC activity
than in untreated samples, suggesting the presence of an inhibitor
(antizyme). ODC inhibitor was detected in plucked skin; inhibitor
levels increased after treatment of plucked skin extracts with
10% (NH4)2SO4.
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