Lin, 1998  Title: Hair growth cycle affects hair follicle
destruction by ruby laser pulses.
Authors: Lin TY, Manuskiatti W, Dierickx CC,
Farinelli WA, Fisher ME, Flotte T, Baden HP, Anderson RR
Journal: J Invest Dermatol 1998 Jul;111(1):107-13
PMID: 9665395, UI: 98328332
Affiliated institution: Wellman Laboratories
of Photomedicine, Department of Dermatology, Massachusetts General
Hospital, Harvard Medical School, Boston 02114, USA.
It has been shown that normal mode ruby laser pulses
(694 nm) are effective in selectively destroying brown or black
pigmented hair follicles in adult Caucasians. This study investigated
how the various stages of the hair follicle growth cycle influence
follicle destruction by ruby laser treatment, using a model of
predictable synchronous hair growth cycles in the infantile and
adolescent mice. A range of ruby laser pulse fluences was delivered
during different stages of the hair growth cycle, followed by
histologic and gross observations of the injury and regrowth of
hair. Actively growing and pigmented anagen stage hair follicles
were sensitive to hair removal by normal mode ruby laser exposure,
whereas catagen and telogen stage hair follicles were resistant
to laser irradiation. Selective thermal injury to follicles was
observed histologically, and hair regrowth was fluence dependent.
In animals exposed during anagen, intermediate fluences induced
nonscarring alopecia, whereas high fluences induced scarring alopecia.
The findings of this study suggest treatment strategies for optimal
laser hair removal.
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