Liew, 1999  Title: The effect of ruby laser light on cellular
proliferation of epidermal cells.
Authors: Liew SH, Grobbelaar AO, Gault DT,
Green CJ, Linge C
Journal: Ann Plast Surg 1999 Nov;43(5):519-22
Affiliated institution: RAFT Institute of Plastic
Surgery, Mount Vernon Hospital, Northwood, Middlesex, UK.
PMID: 10560868, UI: 20023524
Cited in:
In ruby laser-assisted hair removal, microscopic damage is often
seen in the basal epidermal cells, where melanosomes are concentrated.
It is not known whether this treatment leads to cellular hyperproliferation.
It was the aim of this study to investigate this. Ten white patients
were treated with the Chromos 694-nm Depilation Ruby Laser, and
biopsies taken before and after treatments to assess the presence
of cell hyperproliferation, which normally accompanies epidermal
damage, with immunohistochemical staining of keratin 16 and Ki67.
No evidence of cell hyperproliferation was seen in all specimens
examined after ruby laser irradiation. The authors conclude that
despite the possible microscopic damages seen in the basal epidermis
after laser hair removal, there is no evidence of cellular hyperproliferation.
This is in contrast to ultraviolet-irradiated cell damage, in
which increased basal cell turnover is seen.
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