Chang, 1996  Title: Q-switched ruby laser treatment of oculodermal
melanosis (nevus of Ota).
Authors: Chang CJ, Nelson JS, Achauer BM
Journal: Plast Reconstr Surg 1996 Oct;98(5):784-90
PMID: 8823014, UI: 96420315
Affiliated institution: Department
of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital,
Taipei, Taiwan.
Cited in: Solomon
The Q-switched ruby laser at 694 nm, a wavelength
well absorbed by melanin relative to other optically absorbing
structures in skin, causes highly selective destruction of pigment-laden
cells. In addition, the 20- to 40-ns pulse duration produced by
this laser approximates the thermal relaxation time for the melanosomes,
thereby confining the energy to the target. The Q-switched ruby
laser was used to treat 47 patients (11 males and 36 females)
with nevus of Ota during the period December 1991 to 1994. The
involved facial area ranged from 3 x 3 cm2 to 20 x 20 cm2. The
energy fluence used varied from 8 to 10 J/cm2, and the number
of treatments ranged from 1 to 8 (mean 3.4). The results were
graded on the basis of cleaning and fading as follows: poor (0
to 25 percent), fair (26 to 50 percent), good (51 to 75 percent),
and excellent (76 to 100 percent). The mean follow-up period was
15 months. Poor and/or fair results were found in 8 patients who
received one treatment and 7 patients who had two treatments.
Good results were seen in 1 patient who had two treatments, 7
patients who received three treatments, and 3 patients who had
four treatments. Twenty-one patients had excellent results after
three or more treatments of the whole lesion. In conclusion, this
laser system produces clinically significant fading of nevus of
Ota in patients without complications such as hypertrophic scarring
or permanent changes in the normal skin pigmentation.
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