Romsing, 1999  Title: Tetracaine gel vs EMLA cream for percutaneous
anaesthesia in children.
Authors: Romsing J, Henneberg SW, Walther-Larsen
S, Kjeldsen C
Journal: Br J Anaesth 1999 Apr;82(4):637-8
PMID: 10472236, UI: 99401456
Affiliated institution: Department
of Pharmaceutics, Royal Danish School of Pharmacy, Copenhagen,
Denmark.
Cited in:
We have evaluated the anaesthetic effect of tetracaine gel 1
g, applied for 45 min, compared with EMLA cream 2 g, applied for
60 min, in a randomized, double-blind study in 60 children aged
3-15 yr. Venous cannulation was performed 15 min after removal
of the EMLA cream (n = 20) and tetracaine gel (n = 20). Cannulation
was performed up to 215 min after removal of the tetracaine gel
in another 20 patients. Significantly lower pain scores were recorded
by the children treated with tetracaine gel compared with EMLA
cream (P < 0.02). Forty to 45% of children in the tetracaine
groups reported no pain compared with only 10% in the EMLA group.
Only minor adverse effects were observed. We conclude that tetracaine
gel provided effective, rapid, long-lasting and safe local anaesthesia,
and was significantly better than EMLA cream in reducing pain
during venous cannulation in children using the recommended application
periods for both formulations.
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