Kilmer 1994  Title: Treatment of epidermal pigmented lesions
with the frequency-doubled Q-switched Nd:YAG laser. A controlled,
single-impact, dose-response, multicenter trial.
Author: Arch Dermatol 1994 Dec;130(12):1515-9
Journal: Arch Dermatol 1993 Aug;129(8):971-8
PMID: 8352621, UI: 93356572
Affiliated institution: Department
of Dermatology, Wellman Laboratories of Photomedicine, Harvard
Medical School, Boston, Mass.
Cited in: 7986124, UI: 95077456
BACKGROUND AND DESIGN: The removal of benign, aesthetically important,
pigmented lesions can be effectively treated with multiple modalities.
Selective removal of the pigment by lasers is becoming increasingly
popular. A three-center trial evaluated the effectiveness of the
frequency-doubled Q-switched neodymium (Nd):YAG laser (532 nm,
2.0-mm spot size, 10 nanoseconds) in removing benign epidermal
pigmented lesions with a single treatment. Forty-nine patients
were treated for multiple lentigines (n = 37), for cafe au lait
macules (n = 7), and for miscellaneous lesions (n = 5). Treatment
areas were divided into four quadrants, irradiated with fluences
of 2, 3, 4, or 5 J/cm2 and evaluated at 1- and 3-month intervals
following treatment.
RESULTS: For lentigines, response was related to dose with a
greater than 75% pigment removal achieved in 60% of those lesions
treated at higher energy fluences. Responses were more variable
with other lesions, with fair-to-good improvement noted in most
cases. Mild, transient erythema; hypopigmentation; and hyperpigmentation
were noted in several patients, but resolved spontaneously within
3 months. No other textural changes, scarring, or other side effects
were noted.
CONCLUSION: The frequency-doubled Q-switched Nd: YAG laser (532
nm) safely and effectively treats benign epidermal pigmented lesions.
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