Philpott, 1994  Title: Human hair growth in vitro: a model
for the study of hair follicle biology.
Authors: Philpott MP, Sanders D, Westgate GE,
Kealey T
Journal: J Dermatol Sci 1994 Jul;7 Suppl:S55-72
PMID: 7999676, UI: 95092664
Affiliated institution: Department
of Clinical Biochemistry, University of Cambridge, Addenbrookes
Hospital, UK.
Cited in: Solomon
The factors that regulate hair follicle growth are
still poorly understood. In vitro models may be useful in elucidating
some aspects of hair follicle biology. We have developed an in
vitro human hair growth model that enables us to maintain isolated
human hair follicles for up to 10 days, during which time they
continue to grow at an in vivo rate producing a keratinised hair
fibre. We have shown that epidermal growth factor (EGF) in our
system mimics the in vivo depilatory action of EGF in sheep, and
suggest that this occurs as a result of EGF stimulating outer
root sheath (ORS) cell proliferation which results in the disruption
of normal mechanisms of cell-cell interaction in the hair follicle.
We identify transforming growth factor-beta (TGF-beta) as a possible
negative regulator of hair follicle growth and show that physiological
levels of insulin-like growth factor-I (IGF-I) can support the
same rates of hair follicle growth as supraphysiological levels
of insulin. Furthermore, in the absence of insulin hair follicles
show premature entry into a catagen-like state. This is prevented
by physiological levels of IGF-I. Finally we demonstrate that
the hair follicle is an aerobic glycolytic, glutaminolytic tissue
and discuss the possible implications of this metabolism.
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