Paus, 1990  Title: Telogen skin contains an inhibitor of
hair growth.
Authors: Paus R, Stenn KS, Link RE
Journal: Br J Dermatol 1990 Jun;122(6):777-84
PMID: 2369558, UI: 90315303
Affiliated institution: Department
of Dermatology, Yale University School of Medicine, New Haven,
CT 06510.
Cited in: Lin
We have investigated whether C57B1-6 mouse skin
with all its follicles in the telogen stage of the hair cycle
contains a hair-growth inhibitory activity, as opposed to skin
with anagen follicles. Crude aqueous extracts of whole telogen
mouse skin (TE), anagen skin (AE) or vehicle alone (V) were injected
intraperitoneally into mice in which anagen had previously been
induced by plucking of telogen hair follicles. Injection of TE,
but not AE or V, significantly retarded the development of anagen
follicles, as measured by macroscopic and quantitative microscopic
hair growth parameters (skin pigmentation and thickness, appearance
of trichohyaline granules) and the incorporation of tritiated
thymidine into mouse skin from animals previously treated with
either TE or V (skin organ culture). This inhibitory activity
seemed to be localized to the epidermis and was also present in
rat epidermis. We suggest that this apparently non-species-specific
inhibitor present in telogen skin may play a role in regulating
the hair cycle in rodents.
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