Jahoda, 1996  Title: Human hair follicle regeneration following
amputation and grafting into the nude mouse.
Author: Jahoda CA, Oliver RF, Reynolds AJ,
Forrester JC, Horne KA
Publication: J Invest Dermatol 1996 Dec;107(6):804-7
PMID: 8941664, UI: 97096818
Affiliated institution: Department
of Biological Sciences, Durham University, UK.
Cited in:
In this study we investigated the capacity of the human hair
follicle to regenerate a fiber-forming bulb after its amputation.
We removed the bases from terminal follicles from a variety of
sites and transplanted the follicles onto athymic mice, either
still attached to a skin graft or as subcutaneous implants of
individual follicles. External hair growth was observed on the
skin grafts, and histology of the follicles revealed restoration
of dermal papillae and follicle bulb structures. This result suggests
that the capacity of hair follicles to regenerate their lower
structures after removal, which was first demonstrated on whisker
follicles, may be a general phenomenon. It emphasizes the importance
of specific cellular subpopulations within the follicle and the
role of dermal-epidermal interactions in adult follicle activities.
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