Itami, 1995  Title: Androgen induction of follicular epithelial
cell growth is mediated via insulin-like growth factor-I from
dermal papilla cells.
Authors: Itami S, Kurata S, Takayasu S
Journal: Biochem Biophys Res Commun 1995 Jul
26;212(3):988-94
PMID: 7626139, UI: 95352126
Affiliated institution: Department
of Dermatology, Oita Medical University, Japan.
Cited in: Solomon
Androgen significantly stimulates the proliferation
of outer root sheath cells that are cocultured with beard dermal
papilla cells without cell contact. The expression of insulin-like
growth factor I (IGF-I) mRNA in beard dermal papilla cells was
stimulated by androgen and antagonized by cyproterone acetate.
Outer root sheath cells did not express mRNA for IGF-I either
in the presence or absence of androgen. Both of these two types
of cells expressed mRNA for IGF-I receptor and the expression
was not affected by androgen. Neutralizing antibody against IGF-I
antagonized the stimulatory effect of androgen on the growth of
outer root sheath cell cocultured with beard dermal papilla cells.
These findings suggest that IGF-I is a candidate for androgen
induced hair growth factors.
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