Dumesic, 1997  Title: Estimated prevalence of undiagnosed
glucose intolerance from hyperandrogenic anovulation among women
requesting electrolysis.
Author: Dumesic DA, Herrmann RR, O'Brien AM
Journal: Int J Fertil Womens Med 1997 Jul-Aug;42(4):255-60
PMID: 9309459, UI: 97455076
Affiliated institution: Mayo Clinic,
Rochester, Minnesota.
OBJECTIVE: Hyperandrogenic anovulation is the principal risk
factor for non-insulin-dependent diabetes mellitus (NIDDM) in
young women. Since many of these women undergo depilatory therapy,
the purpose of this study was to estimate the probability of undiagnosed
glucose intolerance associated with hyperandrogenic anovulation
among premenopausal women requesting electrolysis.
DESIGN: Case-series study.
INTERVENTIONS: Women (N = 791) attending one of 27 electrology
clinics in the United States, Canada and Germany received questionnaires
requesting anthropometric data; personal information regarding
age, surgery and medication use, and family histories of excess
hair growth in female relatives and diabetes in parents or siblings.
RESULTS: Of 652 respondents less than age 50 years, 643 (98.6%)
women had hirsutism, of whom 465 had regular menstrual cycles.
One hundred seventy-eight (27.3%) women less than 50 years of
age had hirsutism with irregular menses, and one-half of these
women also were obese. Regardless of adiposity, one-third of hirsute
women with menstrual irregularity knew the cause of their androgen
excess, while the remaining two-thirds were unaware of the reason
for their excess hair growth.
CONCLUSIONS: Assuming a 20% risk of glucose intolerance in obese
hyperandrogenic anovulatory women by the fourth decade of life,
the estimated prevalence of undiagnosed glucose intolerance from
hyperandrogenic anovulation is 1.7% among women requesting electrolysis
before age 50 years.
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