Cotsarelis, 1990  Title: Label-retaining cells reside in the
bulge area of pilosebaceous unit: implications for follicular
stem cells, hair cycle and skin carcinogenesis.
Authors: Cotsarelis G, Sun TT, Lavker RM
Journal: Cell 1990;61:1329-37.
PMID: 2364430, UI: 90304891
Affiliated institution: Department
of Dermatology, University of Pennsylvania School of Medicine,
Philadelphia 19104.
Cited in: Williams, Lin
Inconsistent with the view that hair follicle stem
cells reside in the matrix area of the hair bulb, we found that
label-retaining cells exist exclusively in the bulge area of the
mouse hair follicle. The bulge consists of a subpopulation of
outer root sheath cells located in the midportion of the follicle
at the arrector pili muscle attachment site. Keratinocytes in
the bulge area are relatively undifferentiated ultrastructurally.
They are normally slow cycling, but can be stimulated to proliferate
transiently by TPA. Located in a well-protected and nourished
environment, these cells mark the lower end of the "permanent"
portion of the follicle. Our findings, plus a reevaluation of
the literature, suggest that follicular stem cells reside in the
bulge region, instead of the lower bulb. This new view provides
insights into hair cycle control and the possible involvement
of hair follicle stem cells in skin carcinogenesis.
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