Sadick, 1999  Title: High-intensity flashlamp photoepilation:
a clinical, histological, and mechanistic study in human skin.
Authors: Sadick NS, Shea CR, Burchette JL Jr,
Prieto VG
Journal: Arch Dermatol 1999 Jun;135(6):668-76
PMID: 10376694, UI: 99303187
Affiliated institution: Department
of Dermatology, New York Hospital-Cornell Medical Center, New
York, USA.
Cited in :
OBJECTIVE: To examine the clinical, histological, and immunohistological
effects of flashlamp photoepilation.
DESIGN: Nonrandomized control trial with blinded histological
study and follow-up of 1 to 20 months. SETTING: Private academic
practice. SUBJECTS: Sixty-seven subjects (10 males and 57 females)
with areas of excess body hair. INTERVENTIONS: Single (9 subjects)
or multiple (58 subjects) treatments (noncoherent, 590-1200 nm,
2.9-3.0 milliseconds, 40-42 J/cm2) to hairy skin. From subjects
given a single treatment, biopsy samples were taken immediately
after treatment and at different intervals for up to 20 months.
MEAN OUTCOME MEASURES: Clinical measures include hair counts
and morphologic features before and after treatment. Histological
measures include terminal-vellus and anagen-other ratios, hair
shaft diameter, and morphologic features (routine and immunohistochemical
detection of bcl-2, bax, p53, Ki67, cyclin D1, and hsp70) before
and after treatment.
RESULTS: Mean hair loss after photoepilation was 49%, 57%, and
54% for a single treatment and 47%, 56%, and 64% for multiple
treatments at follow-up of less than 3 months, 3 to less than
6 months, and 6 months or longer, respectively (P<.05 for all
comparisons). Transient erythema was seen in all subjects; no
scarring occurred. Histologically, treatment caused morphologic
damage confined to hair follicles and shafts. Terminal-vellus
and anagen-telogen ratios, mean hair shaft diameter, and immunohistochemical
profiles were not significantly modified by treatment. Treatment
did not alter other skin adnexa, epidermis, or vessels.
CONCLUSIONS: Flashlamp treatment leads to significant, longlasting
epilation. The predominant mechanism seems to be via selective
photothermal damage to large, pigmented hair follicles rather
than induction of a programmed state of follicular cycle arrest
or follicular miniaturization.
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