Photodynamic therapy hair removal

Photodynamic therapy

Basic facts

An experimental method combining chemicals and radiation to induce controlled hair loss or reduction.

Description

A chemical is administered which selectively pigments a follicle’s regenerative structures.

Laser or other radiation selectively targets the darkened cells while sparing surrounding tissue.

Advantages

Theoretically could target any hair color.

Disadvantages

Experimental.

Commercial use is not expected in the foreseeable future.

Quack claims

None at this time.

Background

Hair growth cells and cancer cells share some interesting characteristics: rapidly dividing with multiple potentials for differentiation. This is part of the reason many combinations of chemotherapy and radiation result in hair loss: they disrupt the same kinds of cellular activity. [1] It has been theorized that combinations of these drugs and radiation may be used to induce a controlled amount of hair loss or reduction.

History

Photodynamic therapy (PDT) has been useful in treating some types of cancers. [2, 3, 4] Certain chemicals have been observed to darken some types of skin cells, [5] which can then be selectively targeted by laser to induce apoptosis or “programmed cell death.” [6] Recent data suggests PDT may have uses in the treatment of acne as well. [7]

In addition, the presence or absence of certain genetic markers in mice such as p53 have been observed to be “on-off” switches for chemical/radiation induced hair loss. [8] Learning to manipulate genetic markers like these in conjunction with chemicals and/or radiation may lead to new hair reduction treatments.

Clinical data

This has been proposed as a theoretical possibility of hair removal, and in 1995 an experimental clinical trial was performed. [9] However, commercial use of the procedure is not expected in the near future.

References

  1. Thatte U, Bagadey S, Dahanukar S. Modulation of programmed cell death by medicinal plants. Cellular and Molecular Biology (Noisy-le-grand) 2000 Feb;46(1):199-214.
  2. De Rosa FS, Bentley MV. Photodynamic therapy of skin cancers: sensitizers, clinical studies and future directives. Pharmaceutical Research 2000 Dec;17(12):1447-55.
  3. Morton CA and others. Photodynamic therapy for large or multiple patches of Bowen disease and basal cell carcinoma. Archives of Dermatology. 2001 Mar;137(3):319-24.
  4. Guillen C and others. Photodynamic therapy for in situ squamous cell carcinoma on chronic radiation dermatitis after photosensitization with 5-aminolaevulinic acid. Journal of the European Academy of Dermatology and Venereology. 2000 Jul;14(4):298-300.
  5. Kalka K, Merk H, Mukhtar H. Photodynamic therapy in dermatology. Journal of the American Academy of Dermatology 2000 Mar;42(3):389-413; quiz 414-6.
  6. Granville DJ, McManus BM, Hunt DW. Photodynamic therapy: shedding light on the biochemical pathways regulating porphyrin-mediated cell death. Histology and Histopathology 2001 Jan;16(1):309-17.
  7. Hongcharu W and others. Topical ALA-photodynamic therapy for the treatment of acne vulgaris. Journal of Investigative Dermatology 2000 Aug;115(2):183-92.
  8. Botchkarev VA and others. p53 is essential for chemotherapy-induced hair loss. Cancer Research 2000 Sep 15;60(18):5002-6.
  9. Grossman MC, Wimberely J, Dwyer P, Flotte TJ, Anderson RR. PDT for hirsutism. Lasers in Surgery and Medicine (supplement) 7 : 44,1995.

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